Do We Achieve target Lipid Levels with Statins in Patients with Coronary Artery Disease?

  • S Harikrishnan Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.
  • E Rajeev Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.
  • Jaganmohan A Tharakan Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum
  • T Titus Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum
  • V K Ajithkumar Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum
  • S Sivasankaran Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum
  • K M Krishnamoorthy Sree Chitra Thirunal Institute of Medical Scienes and Technology, Trivandrum
  • Krishnakumar Nair Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.
DOI: https://doi.org/10.52314/kmj.2008.v1i1.92
Keywords: Statins, Cholesterol, Target Lipoprotein Levels, Coronary

Abstract

The lipid profile of 852 consecutive angiographically proven coronary artery disease(CAD) patients, who were on primary treatment with statins were analyzed to see whether they have achieved target Adult Treatment Panel III (ATPIII) goals. Mean age of the population was 53.6 +/- 7.9 years and there were 645 males (75.7%). These patients were on statins for a minimum period of 6 months (average 10.3 + 2.2 months). Lipid values before initiation of statin treatment were available only in 446 patients. 72% of the patients were taking atorvastatin (mean dose 15.9mg), 23% were on simvastatin (mean dose 16.0mg) and 4% were on lovastatin (14.5mg) at follow up. Only 359 (42.2%) of patients achieved low-density lipoprotein cholesterol goal of <100mg% on treatment with statins. 59.1% of the population were having a high density lipoprotein levels > 40 mg%. Triglyceride levels <150 mg% was seen in 81% of the study population. This data is in accordance with studies in the western population. This finding addresses to the need for better strategies in clinical practice to achieve lipid targets. The causes of the problem and the possible solutions are discussed.

Author Biographies

S Harikrishnan, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.

Associate Professor, Lipid Clinic, Department of Cardiology

E Rajeev, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.

Department of Cardiology

Jaganmohan A Tharakan, Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum

Professor, Department of Cardiology

T Titus, Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum

Professor, Department of Cardiology

V K Ajithkumar, Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum

Professor, Department of Cardiology

S Sivasankaran, Sree Chitra Thirunal Institute of Medical Sciences and Technology, Trivandrum

Professor, Department of Cardiology

K M Krishnamoorthy, Sree Chitra Thirunal Institute of Medical Scienes and Technology, Trivandrum

Professor, Department of Cardiology

Krishnakumar Nair, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum-695011.

Department of Cardiology

Published
2017-09-30
How to Cite
Harikrishnan, S., Rajeev, E., Tharakan, J., Titus, T., Ajithkumar, V., Sivasankaran, S., Krishnamoorthy, K., & Nair, K. (2017). Do We Achieve target Lipid Levels with Statins in Patients with Coronary Artery Disease?. Kerala Medical Journal, 1(1), 9-13. https://doi.org/10.52314/kmj.2008.v1i1.92
Issue
Vol 1 No 1 (2008): July to September 2008
Section
Original Research

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