Liraglutide: First Once-Daily Human GLP-1 Analogue

  • Sreejith N Kumar Research Cell, IMA Kerala State, K-5, Kochar Road, Sasthamangalam, Thiruvananthapuram-695010
Keywords: GLP 1 Analogue, Liraglutide, Incretin, Hypoglycemia, Weight loss

Abstract

The gastrointestinal hormones glucose- dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), termed incretins, are essential regulators of normal glucose homeostasis. The drug substance, Liraglutide, is a long acting analogue of the naturally occurring human GLP-1 (7-37) with 97% homology and a lipophilic substituent for prolongation of half life.
Liraglutide is available in a pre-filled, multi-dose pen-injector containing 6.0 mg/ml of the drug substance in solution presented for subcutaneous injection.
Liraglutide provided significantly better glycemic control than Rosglitazone or insulin glargine in combination trials. Liraglutide improved pancreatic beta-cell function, consistently led to weight loss, and was associated with a low risk of hypoglycaemia. Liraglutide was generally well tolerated, with the most common adverse events being gastrointestinal events, such as nausea, which decreased over time.

Author Biography

Sreejith N Kumar, Research Cell, IMA Kerala State, K-5, Kochar Road, Sasthamangalam, Thiruvananthapuram-695010

Convener

Published
2011-06-30
How to Cite
Kumar, S. (2011). Liraglutide: First Once-Daily Human GLP-1 Analogue. Kerala Medical Journal, 4(2), 68-72. https://doi.org/10.52314/kmj.2011.v4i2.219
Section
Drug Profile