A V Jayakrishnan
EMS Memorial Co-operative Hospital, Perinthalmanna

Corresponding Author: Dr. A V Jayakrishnan, Neuro Surgeon, EMS Memorial Co-operative Hospital, Perinthalmanna Mobile: 98470 04064, 94470 79074, Email: jkvikram@hotmail.com

ABSTRACT

Levetiracetam is indicated as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy. Levetiracetam is indicated as adjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy. Levetiracetam is indicated as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in adults and children 6 years of age and older with idiopathic generalized epilepsy.

Pharmacology

The chemical name of levetiracetam, a single enantiomer, is (-)-(S)-á-ethyl-2-oxo-1-pyrrolidine acetamide, its molecular formula is C8H14N2O2 and its molecular weight is 170.21. Levetiracetam is chemically unrelated to existing antiepileptic drugs (AEDs).

Indications

Levetiracetam is indicated as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy. Levetiracetam is indicated as adjunctive therapy in the treatment of myoclonic seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy. Levetiracetam is indicated as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in adults and children 6 years of age and older with idiopathic generalized epilepsy.

Dosage & Administration

Partial onset Seizures
Adults 16 years  and older

In clinical trials, daily doses of 1000 mg, 2000 mg, and 3000 mg, given as twice-daily dosing, were shown to be effective.

Pediatric Patients Ages 4 To < 16 Years

Treatment should be initiated with a daily dose of 20 mg/kg in 2 divided doses (10 mg/kg BID). The daily dose should be increased every 2 weeks by increments of 20 mg/kg to the recommended daily dose of 60 mg/kg (30 mg/kg BID).

Myoclonic Seizures In Patients 12 Years Of Age And Older With Juvenile Myoclonic Epilepsy

Treatment should be initiated with a dose of 1000 mg/day, given as twice-daily dosing (500 mg BID). Dosage should be increased by 1000 mg/day every 2 weeks to the recommended daily dose of 3000 mg

Primary  Generalized  Tonic-Clonic Seizures

Adults 16 years and older

Treatment should be initiated with a dose of 1000 mg/day, given as twice-daily dosing (500 mg BID). Dosage should be increased by 1000 mg/day every 2 weeks to the recommended daily dose of 3000 mg

Adverse effects: were somnolence, asthenia, infection and dizziness, abdominal pain, amblyopia, arthralgia, back pain, bronchitis, chest pain, confusion, constipation, convulsion, diarrhea, dyspepsia, ecchymosis, fever, flu syndrome, fungal infection, gastroenteritis, gingivitis, grand mal convulsion, insomnia, nausea, otitis media, rash, abnormal thinking , tremor, urinary tract infection, vomiting and weight gain.

End Note

Author Information

Dr. A V Jayakrishnan, Neuro Surgeon,
EMS Memorial Co-operative Hospital,
Perinthalmanna
Mobile: 98470 04064, 94470 79074,
Email: jkvikram@hotmail.com   

Conflict of Interest: None declared

References

  1. Levetiracetam – Wikipedia, the free encyclopedia. [Source]
  2. Levetiracetam (Oral Route) Description and Brand Names – Mayo clinic Patient Care and Health Info. [Source]