MV Francis
Eye and Migraine Centre, Cherthala, Alleppey District, Kerala, India

Corresponding Author: Dr. MV Francis, MS, Chief Consultant, Eye and Migraine Centre, Cherthala, Alleppey District, Kerala, India. E-mail: mvfrancis@ rediffmail.com Phone: +91-478-2821091

ABSTRACT

Objective: Evaluation of abdominal pains of menstrual origin in mothers of children with migraine.

Materials and Methods: A study spanning 4 years, from April 2004 to September 2008 was done. The study was conducted at the Eye and Migraine Centre, Cherthala and St. Sebastian’s Visitation Hospital, Arthunkal. Four thousand mothers with migraine (migraine without aura, with aura and probable migraine) were queried regarding menstrual pains (head pain and abdominal pain) when they presented with their children who had headaches of migraine origin.

Results: While only 14 per cent (562) had menstrual migraine (day 1 plus or minus 2 days of menstrual cycle), 72 per cent (2882) reported dysmenorrhoea, either at the time of presentation or sometime in the past (mostly before first pregnancy) and in 61 per cent (2441) of them, severe lower abdominal pain similar to dysmenorrhoea was associated with anorexia/ nausea/ vomiting/ phonophobia and photophobia, all suggestive of a diagnosis of lower abdominal migraine.

Conclusion: The present study concludes that lower abdominal pains resembling abdominal migraines are very common in female migraineurs during menstruation and it can occur without typical I H S (International Headache Society) migraine or probable migraine head pain. Dysmenorrhoea, present or past, must be specifically enquired into, while taking headache history from mothers. If severe lower abdominal pains with migraine-associated features are present, it can be considered as lower abdominal migraine or migraine trait. This history helps in diagnosing early migraines in their children easier.

Introduction

For centuries, women with migraine have been labeled neurotic – a not so uncommon explanation for conditions linked to hormones. Women have headaches more commonly than men. Specific hormonal events during the reproductive years have a profound influence on migraine in women. Onset of migraine is usually after menarche, during the teens and early 20s. Prevalence of migraine peaks during the early 40s and improves post-menopause. At this time, many women report an association between migraine without aura and menstruation, with attacks most  likely  to occur  on  or around the first  day  of bleeding. Although studies suggest that withdrawal of estrogen in  the  late  luteal phase  of the  normal menstrual cycle is involved in  the  mechanism of menstrual migraine, it is not  well  understood how exactly the  changes in  estrogen levels influence migraine. Fluctuations in estrogen levels can cause prostaglandin release and changes in neurotramsmitters, including noradrenaline, serotonin, dopamine and endorphins.

As part of documenting various common diagnostic migraine triggers including menstruation, during the early part of my Periorbital Headache1 study, which started in 1993, a chance observation was made on the relationship between migraine and dysmenorrhea.2 This was prior to the publication of ICHD-2 (International classification of headache disorders)in  2004.  Many female migraine patients, when interviewed, reported severe lower abdominal pains with migraine-associated features (anorexia, nausea, vomiting, phonophobia and photophobia) rather than migraine head pains of menstrual origin. A prospective study was undertaken to document these abdominal pains based on ICHD-2 diagnostic criteria.3

Materials and Methods

Four thousand mothers with migraine in the age group of 30 to 60 years attending the out-patient departments from April 2004 to September 2008 were included in the  study. Migraine and its sub-types including abdominal migraines were diagnosed according to ICHD-2 diagnostic criteria published in 2004.

Diagnostic criteria for abdominal migraine:

  • Five attacks
  • 1 to 72 hours duration
  • Midline location, periumbilical or poorly localized
  • Dull or just sore in quality
  • Of moderate or severe intensity
  • During abdominal pain, at least 2 of the following associated features (anorexia/nausea /vomiting /pallor)
  • Not attributed to another disorder (particularly if history and physical examination do not show signs of gastrointestinal or renal disease, or such disease has been ruled out by appropriate investigations)

Results

Table 1. A total number of 4000 mothers were interviewed. The types of migraines diagnosed are included

Table 1. A total number of 4000 mothers were interviewed. The types of migraines diagnosed are included

Menstrual migraine was found only in 14 per cent (562) of mothers and dysmenorrhoea in 72 per cent (2882). Severe dysmenorrhoea with migraine associated features was found in 61 per cent (2441).

Area of pain: Other than lower abdominal region, periumbilical, suprapubic, lower back, upper thigh and legs also were involved in majority of the women studied.

Quality of pain: Different descriptions such  as migraine pain, sharp, throbbing, dull ache, burning, shooting pain and pains that are inexplicable.

Associated features: Anorexia  and nausea  (431), anorexia and vomiting (677), nausea and phonophobia (543), anorexia, phonophobia and photophobia (402), all associated symptoms (388).

Pallor is one of the associated features in paediatric abdominal migraine but was not reported by any of the migraine-affected mothers in this study.

Duration of pain: A large majority (82 per cent) reported pain lasting one whole day. Like brief migraine headaches and abdominal migraines, it lasted for 30 minutes to 3 hours in 16 per cent of patients. The remaining reported duration of pain varying from more than one day to the end of menstruation.In62 per cent, pain subsided after the first pregnancy and in 14 per cent it reappeared either after second or third delivery or later without any apparent reason. Eight percent of women started experiencing dysmenorrhic symptoms either after their first or second deliveries.

Nearly three out of five women described their pain as severe, affecting their day to day activities. The rest described it as mild to moderate which hindered their daily activities but could cope with it. The other migraine-related symptoms reported were dizziness and vertigo, increased appetite, bad temper, irritability, fatigue, diarrhea, increased urination, confusion, disorientation and lack of energy.

Discussion

Headache classification committee of the International Headache Society has not yet agreed on a definition for menstrual migraine. It is included in the Appendix Criteria3 as they have not been sufficiently validated by research studies and due to uncertainty over whether they should be regarded as  separate entities. Abdominal migraines are included in  the official criteria as  a part  of  Childhood  Periodic Syndromes; the  other  entities in this  subgroup are Cyclical Vomiting  and  Benign Paroxysmal Vertigo of childhood. These syndromes are rare in clinical practice and no significant studies have been done in India and other Asian countries.

The current study found that the percentage of migraine-affected women who report menstrual – origin abdominal pain is significantly high.

To the best of my knowledge (Medline search), this is the first study to document a correlation between migraine, menstruation and lower abdominal pains. This study shows that more than 60per cent of female migraineurs suffer from severe lower abdominal pains resembling abdominal migraines in children and adolescents. During the study period  of 4 years,  66 non-migraine-affected mothers reported severe dysmenorrhea with migrainous autonomic symptoms which helped in diagnosing brief or early migraines in their children.4

Balbi and colleagues,5 cite  85 per cent  of 14-21 year age group suffers from dysmenorrhea whereas Coco6 shows prevalence of 90 per cent. A study done  on  a Belgian group aged  15  to 24 years, the prevalence rate  was  only  42 per cent.7 None of these studies have dealt  with migraine.

According to Coco, primary dysmenorrhea is so common that many women fail to report it in medical interviews, even when their daily activities are restricted. This study supports that observation. Most of these mothers and their daughters are told by the older women in  the  family that  these pains are physiological and no need of any medications other than usual home remedies.

Most  of  the mothers claim  to  adapt  well  to some monthly hindrance of their  activities but their daughters always wanted relief  from these pains provided the drugs prescribed are safe. Some medical practitioners also have  contributed to their fears  by stating  that it is always better  to avoid  medications for dysmenorrhea. Some of them opted for complimentary and alternative medications because of such advice.

While abdominal migraines are  seen in  female children before menarche, studies show  that  most children with abdominal migraine will  develop migraine headache later in life. Migraine-associated features involving the  gastrointestinal tract, like vomiting, nausea and diarrhoea8,9 were the most distressing symptoms in many dysmenorrhic mothers. Premonitory migraine symptoms (occurring hours to days before headache) such  as  fatigue, lethargy, disorientation, anger and rage too were reported by some. These  symptoms are  now  considered to  be part of the broader syndrome named  Premenstrual Syndrome (PMS) with  more than  200  different symptoms identified or  Premenstrual Dysphoric Disorder, a more  severe form of PMS.

The  results of this  study  on  the  characteristic of menstrual abdominal pain  and  how  it  is handled, clearly reinforce currently available data that severe dysmenorrhea is a  syndrome that seriously undermines the quality of life of the women affected, just  like  migraine head-pain and  thus  requires a thorough therapeutic approach by  health care professionals.

Conclusion

All  women with  migraine are  susceptible to  the effects of hormonal changes. Migraine and  severe dysmenorrhea are  remarkably common causes of temporary disability.  Still many  women, even those with disabling pains, have never consulted a physician for  the  problem. Severe lower abdominal pains resembling abdominal migraines in children are very common in female migraineurs during menstruation, and it can occur without typical I H S migraine or probable migraine head-pains. Dysmenorrhic symptoms with migrainous autonomic features which affect  daily  activities must be specifically enquired into while  taking  headache history. If severe  lower abdominal pain,  along  with  migraine-associated features is present, it can be considered as a migraine trait or lower abdominal migraine. Diagnosing early or brief migraine in their children will be made simpler in such circumstances.

End Note

Author Information

Dr. MV Francis, MS, Chief Consultant,
Eye and Migraine Centre, Cherthala, Alleppey  District, Kerala, India. Phone: +91-478-2821091.
E-mail: mvfrancis@ rediffmail.com

Conflict of Interest: None declared

Acknowledgment

  1. Dr. U S Nayak, Consultant Paediatrician, Cherthala
  2. Dr. Joseph V Francis, Associate Prof. Surgery,
    Co­ operative Medical College, Kochi
  3. Dr. Manoj Babu R, Consultant Gynaecologist, SSH Arthunkal, Cherthala

References

  1. M V  Francis and  U S  Nayak:  Periorbital Headaches in a South Indian population- a 7-year study. Cephalalgia  vol. 21, No 4, May 2001 P521 (poster presented at  the  lOth Congress of  the International Headache Society, New York 2001)
  2. M V Francis: Dysmenorrhoea – a migraine trait or abdominal  migraine?  Journal of Headache  and Pain, vol.  5,  No 1, April  2004  P61  (abstract of platform presentation in the VI International Congress on Headache  in Children  and Adolescents, Vienna 2004)
  3. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 2004;24 Suppl 1:9–160. [Pubmed] | [Source]
  4. Francis MV. Brief migraine episodes in children and adolescents-a modification to International Headache Society pediatric migraine (without aura) diagnostic criteria. Springerplus [Internet]. 2013 Mar 4 [cited 2015 Oct 1];2. [Pubmed] | [Crossref]
  5. Balbi C, Musone R, Menditto A, Di Prisco L, Cassese E, D’Ajello M, et al. Influence of menstrual factors and dietary habits on menstrual pain in adolescence age. Eur J Obstet Gynecol Reprod Biol. 2000 Aug;91(2):143–8. [Pubmed] | [Source]
  6. Coco AS: Primary Dysmenorrhea,  Am Family Physician 1999: 60: Pages 489-496. [Source]
  7. Hugues D Malonne and  Jet  Van Hoek:  The Experience of Menstrual  pain in Belgian women. Proceedings on the 10th World Congress on pain, San Diego, Progress in Pain Research and Management vol. 24 IASP press Seattle  2003
  8. Wolfs: Headache and other Head pain, 7th Edition. Editors: Stephen D Silberstein, Richard B Lipton and Donald J Dalessio  Pages 121 -210
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